Gene information
Official symbol PPARA
Official full name peroxisome proliferator activated receptor alpha
Gene type protein-coding gene
Chromosome22q13.31
Alias symbolhPPAR; NR1C1
Previous symbolPPAR
Gene familyNuclear hormone receptors
Resources
Entrez Gene 5465
HGNC HGNC:9232
Ensembl ENSG00000186951
Vega OTTHUMG00000150443
UCSC uc003bgx.1
GO terms: 165 records
GO Description Category LogP Number of genes Detail
GO:0001221 transcription coregulator binding GO Molecular Functions -4.88806294 16 More
GO:0001223 transcription coactivator binding GO Molecular Functions -2.21174835 6 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0004879 nuclear receptor activity GO Molecular Functions -3.42635044 5 More
GO:0006109 regulation of carbohydrate metabolic process GO Biological Processes -13.1742479 35 More
GO:0006110 regulation of glycolytic process GO Biological Processes -6.41532756 12 More
GO:0006140 regulation of nucleotide metabolic process GO Biological Processes -7.41911571 18 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007623 circadian rhythm GO Biological Processes -8.17635164 13 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008134 transcription factor binding GO Molecular Functions -5.50998540 50 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009267 cellular response to starvation GO Biological Processes -4.23113258 19 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009755 hormone-mediated signaling pathway GO Biological Processes -4.05849698 16 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010611 regulation of cardiac muscle hypertrophy GO Biological Processes -13.5611908 22 More
GO:0010675 regulation of cellular carbohydrate metabolic process GO Biological Processes -9.60411715 27 More
GO:0010676 positive regulation of cellular carbohydrate metabolic process GO Biological Processes -6.37680507 13 More
GO:0010677 negative regulation of cellular carbohydrate metabolic process GO Biological Processes -4.04738042 9 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010745 negative regulation of macrophage derived foam cell differentiation GO Biological Processes -12.3554756 8 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0010883 regulation of lipid storage GO Biological Processes -22.5241589 19 More
GO:0010885 regulation of cholesterol storage GO Biological Processes -14.3909835 10 More
GO:0010887 negative regulation of cholesterol storage GO Biological Processes -7.00336814 5 More
GO:0010888 negative regulation of lipid storage GO Biological Processes -13.5596033 10 More
GO:0010889 regulation of sequestering of triglyceride GO Biological Processes -3.16989067 3 More
GO:0010906 regulation of glucose metabolic process GO Biological Processes -10.3110629 25 More
GO:0010907 positive regulation of glucose metabolic process GO Biological Processes -8.00848642 13 More
GO:0014741 negative regulation of muscle hypertrophy GO Biological Processes -8.77845673 13 More
GO:0014743 regulation of muscle hypertrophy GO Biological Processes -14.1608908 23 More
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO Biological Processes -7.26381098 23 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019217 regulation of fatty acid metabolic process GO Biological Processes -12.5607102 15 More
GO:0019902 phosphatase binding GO Molecular Functions -2.86314983 18 More
GO:0022408 negative regulation of cell-cell adhesion GO Biological Processes -15.9068791 40 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030308 negative regulation of cell growth GO Biological Processes -7.25826751 14 More
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO Biological Processes -4.17150859 14 More
GO:0030522 intracellular receptor signaling pathway GO Biological Processes -2.78567165 7 More
GO:0030534 adult behavior GO Biological Processes -6.59104580 21 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0031669 cellular response to nutrient levels GO Biological Processes -9.42886914 32 More
GO:0031998 regulation of fatty acid beta-oxidation GO Biological Processes -2.92503639 5 More
GO:0032091 negative regulation of protein binding GO Biological Processes -7.69848876 11 More
GO:0032096 negative regulation of response to food GO Biological Processes -4.31351457 5 More
GO:0032098 regulation of appetite GO Biological Processes -7.13135320 9 More
GO:0032099 negative regulation of appetite GO Biological Processes -4.31351457 5 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032104 regulation of response to extracellular stimulus GO Biological Processes -5.26554247 8 More
GO:0032105 negative regulation of response to extracellular stimulus GO Biological Processes -4.31351457 5 More
GO:0032107 regulation of response to nutrient levels GO Biological Processes -5.26554247 8 More
GO:0032108 negative regulation of response to nutrient levels GO Biological Processes -4.31351457 5 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032890 regulation of organic acid transport GO Biological Processes -14.1608908 23 More
GO:0032922 circadian regulation of gene expression GO Biological Processes -4.74914851 7 More
GO:0035094 response to nicotine GO Biological Processes -8.07167727 14 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0042157 lipoprotein metabolic process GO Biological Processes -6.61578697 11 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042475 odontogenesis of dentin-containing tooth GO Biological Processes -4.56077482 13 More
GO:0042476 odontogenesis GO Biological Processes -9.69427751 24 More
GO:0042594 response to starvation GO Biological Processes -5.43370462 24 More
GO:0042752 regulation of circadian rhythm GO Biological Processes -4.07022867 8 More
GO:0043255 regulation of carbohydrate biosynthetic process GO Biological Processes -8.87798147 21 More
GO:0043393 regulation of protein binding GO Biological Processes -7.80142307 15 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043467 regulation of generation of precursor metabolites and energy GO Biological Processes -10.8295915 27 More
GO:0043470 regulation of carbohydrate catabolic process GO Biological Processes -8.06132628 15 More
GO:0043502 regulation of muscle adaptation GO Biological Processes -16.8828965 29 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045069 regulation of viral genome replication GO Biological Processes -1.96545001 9 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045722 positive regulation of gluconeogenesis GO Biological Processes -3.15220350 5 More
GO:0045776 negative regulation of blood pressure GO Biological Processes -17.1357953 22 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045912 negative regulation of carbohydrate metabolic process GO Biological Processes -5.15495164 11 More
GO:0045913 positive regulation of carbohydrate metabolic process GO Biological Processes -10.1978214 20 More
GO:0045923 positive regulation of fatty acid metabolic process GO Biological Processes -10.6446744 10 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0045981 positive regulation of nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:0046320 regulation of fatty acid oxidation GO Biological Processes -3.51698265 7 More
GO:0046620 regulation of organ growth GO Biological Processes -13.2396968 26 More
GO:0046621 negative regulation of organ growth GO Biological Processes -3.90789529 8 More
GO:0046889 positive regulation of lipid biosynthetic process GO Biological Processes -14.1380112 16 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0048511 rhythmic process GO Biological Processes -10.3377021 38 More
GO:0048524 positive regulation of viral process GO Biological Processes -2.4114088 8 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048640 negative regulation of developmental growth GO Biological Processes -7.44784067 20 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050792 regulation of viral process GO Biological Processes -4.90676471 20 More
GO:0050994 regulation of lipid catabolic process GO Biological Processes -9.86212956 11 More
GO:0050996 positive regulation of lipid catabolic process GO Biological Processes -5.87603013 9 More
GO:0051098 regulation of binding GO Biological Processes -15.8856010 30 More
GO:0051100 negative regulation of binding GO Biological Processes -8.85516089 15 More
GO:0051148 negative regulation of muscle cell differentiation GO Biological Processes -3.93077688 11 More
GO:0051153 regulation of striated muscle cell differentiation GO Biological Processes -11.0877013 23 More
GO:0051154 negative regulation of striated muscle cell differentiation GO Biological Processes -2.96833359 7 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051898 negative regulation of protein kinase B signaling GO Biological Processes -8.06132628 15 More
GO:0055021 regulation of cardiac muscle tissue growth GO Biological Processes -9.70685856 18 More
GO:0060420 regulation of heart growth GO Biological Processes -10.7642352 20 More
GO:0061050 regulation of cell growth involved in cardiac muscle cell development GO Biological Processes -6.11772924 8 More
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding GO Molecular Functions -8.00802452 40 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0062014 negative regulation of small molecule metabolic process GO Biological Processes -11.3582124 24 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071383 cellular response to steroid hormone stimulus GO Biological Processes -3.35454241 16 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -13.1150464 44 More
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -4.61411692 19 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0097305 response to alcohol GO Biological Processes -17.4096682 46 More
GO:0098531 ligand-activated transcription factor activity GO Molecular Functions -3.42635044 5 More
GO:0140297 DNA-binding transcription factor binding GO Molecular Functions -6.94737226 46 More
GO:1900542 regulation of purine nucleotide metabolic process GO Biological Processes -7.57719972 18 More
GO:1900544 positive regulation of purine nucleotide metabolic process GO Biological Processes -9.35726225 15 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1902893 regulation of miRNA transcription GO Biological Processes -10.5909336 18 More
GO:1902894 negative regulation of miRNA transcription GO Biological Processes -3.03478521 5 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903038 negative regulation of leukocyte cell-cell adhesion GO Biological Processes -10.2281373 27 More
GO:1903426 regulation of reactive oxygen species biosynthetic process GO Biological Processes -7.23199669 13 More
GO:1903578 regulation of ATP metabolic process GO Biological Processes -8.20286273 19 More
GO:1903580 positive regulation of ATP metabolic process GO Biological Processes -9.55155535 14 More
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO Biological Processes -8.41113232 25 More
GO:1903900 regulation of viral life cycle GO Biological Processes -3.59662203 16 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904036 negative regulation of epithelial cell apoptotic process GO Biological Processes -12.0631217 12 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:2000191 regulation of fatty acid transport GO Biological Processes -10.7141263 14 More
GO:2000272 negative regulation of signaling receptor activity GO Biological Processes -7.12747015 9 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
GO:2000378 negative regulation of reactive oxygen species metabolic process GO Biological Processes -8.33338139 14 More
KEGG pathways: 7 records
KEGG Description Category LogP Number of genes Detail
hsa03320 PPAR signaling pathway KEGG Pathway -10.0668076 12 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04920 Adipocytokine signaling pathway KEGG Pathway -10.4150431 19 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa05160 Hepatitis C KEGG Pathway -4.71256920 10 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
Drug-Gene interaction
view
Related drugs: 57 records
Drug name Interaction type Source PMID View
aleglitazar agonist TdgClinicalTrialChemblInteractions 2065332710592235 view
ave8134 agonist ChemblInteractions view
bezafibrate agonist TdgClinicalTrialTENDTTD 1862935616511610111724671142273211519881109099821175235210933891 view
bithionol DTC view
bromoxynil DTC view
chembl107518 DTC 22487179 view
chembl1089501 DTC 20218621 view
chembl118417 DTC view
chembl153057 DTC view
chembl220087 DTC view
chembl259327 DTC view
chembl292352 DTC view
chembl38508 DTC view
choline fenofibrate agonist ChemblInteractions view
ciglitazone DTC 23566516 view
ciprofibrate agonist DTCTTD 16731579 view
clofibrate agonist TdgClinicalTrialChemblInteractionsTEND 10787442109224592063782310951268206710721045450110753628 view
cp-778875 agonist ChemblInteractions view
drf-10945 agonist ChemblInteractions view
elafibranor TTD view
fenofibrate agonist TdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 1079931711018525108280601147448610494028113425371175235215608561 view
fenofibric acid agonist DTCChemblInteractions 225794842185533323566516 view
gemfibrozil agonist DTCTdgClinicalTrialChemblInteractionsTEND 122440381293532312834305121723981049402821889235 view
gw501516 agonist DTCTdgClinicalTrial 2356651623843199 view
gw590735 agonist ChemblInteractions 10592235 view
gw7647 agonist DTC 23102891186655812317104518162399 view
iloprost activator TALC view
imiglitazar agonist ChemblInteractionsTTD view
indeglitazar agonist ChemblInteractions 10592235 view
ioxynil DTC view
k-877 agonist ChemblInteractionsTTD view
lactofen DTC view
linoleic acid DTC view
lobeglitazone TTD view
lxr-623 DTC 20350005 view
ly-518674 agonist TdgClinicalTrialChemblInteractionsTTD view
metformin PharmGKB 24853734 view
muraglitazar agonist TdgClinicalTrialChemblInteractionsTTD view
myristic acid DTC 10403814 view
naveglitazar agonist TdgClinicalTrialChemblInteractionsTTD view
oleic acid DTC view
oleoylethanolamide DTC 2607163917228882 view
oxeglitazar TTD view
phenformin hydrochloride DTC view
phenprocoumon PharmGKB 25461249 view
pirinixic acid DTC 231710451722888225497132 view
prostaglandin d2 DTC 23566516 view
ragaglitazar agonist TTD 1297008816240504 view
romazarit TTD 23515070 view
simvastatin PharmGKB 239306762459871823252946 view
sodelglitazar agonist ChemblInteractions view
t091317 DTC 20350005 view
tacrolimus PharmGKB 246588272411321629399716 view
tesaglitazar agonist ChemblInteractionsTTD 16168052 view
tetradecylthioacetic acid DTC 20036122 view
ursolic acid DTC 21855333 view
zyh7 agonist ChemblInteractions view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
NM_005036.6:c.1047+2528C>G genomics myocardial infarction[diagnosis] myocardial infarction Doney AS et al. Nucl Recept. 2005
NM_005036.6:c.[-127+5156G>A;-127+7452C>A;-127+11398A>C] genomics myocardial infarction[diagnosis] myocardial infarction Reinhard W et al. Clin Sci (Lond). 2008
NM_005036.6:c.484C>G genomics myocardial infarction[diagnosis] myocardial infarction Doney AS et al. Nucl Recept. 2005
NM_005036.6:c.-127+5156G>A genomics myocardial infarction[diagnosis] myocardial infarction Reinhard W et al. Clin Sci (Lond). 2008
NM_005036.6:c.-127+2233A>G genomics myocardial infarction[diagnosis] myocardial infarction Enquobahrie DA et al. Am J Cardiol. 2008
All rights reserved: Soochow University Center for Systems Biology